The Inferred Allele Review Committee (IARC) is a committee of the Adaptive Immune Receptor Repertoire (AIRR) Community Committee of The Antibody Society whose mission is to validate human IG and TR germline V gene allelic sequences that have been inferred from next-generation sequencing data. IG and TR germline V gene sequences can also be deduced from next-generation sequencing data from a B- or T-cell receptor repertoire. Please contact us if you would like to submit sequences for review and approval.Ĭlick here for a description of the current submission procedure. Note: The appropriate procedures and submission forms are currently being developed. Validated IG and TR germline gene sequences and their names are passed to partner databases for curation and inclusion in germline gene/allele sets. Working with the submitters, members of this Review Committee review and approve sequences and names, based on specific data-driven criteria and review processes. Scientists submit sequences for new IG and TR variable (V), diversity (D), joining (J) and constant (C) genes and alleles to the TR-IG Review Committee. Germline gene submission for review and approval: Yana Safonova (Johns Hopkins webpage) 2022Ĭontact: with subject line “Attention TR-IG Review Committee” Luc Teyton (Scripps Research webpage) 2022 Henk-Jan van den Ham (ENPICOM LinkedIn) 2022 TR-IG has been tasked with developing methods and procedures for reviewing new TR and IG genes for inclusion in databases.Īndrew Collins (University of New South Wales webpage) 2022Įlisa Rosati Scalchi (GSK Linkedin) 2022Ĭorey Watson (University of Louisville webpage) 2022 This function was previously performed by the IMGT-NC Reports Review Committee, which was replaced by an elected body in October 2022 and was renamed as the TR-IG Review Committee in March 2023. It evaluates, names, and reports new germline genes encoding immunoglobulins (IG) and T-cell receptors (TR). The TR-IG Review Committee was established by the IUIS IG/TR/MH Nomenclature Sub-Committee. TR-IG Review Committee (formerly IMGT-NC Reports Review Committee) IUIS NOM Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility (MH) Nomenclature Sub-committee (IMGT-NC) You will find information about the history of the Sub-Committee since its creation and annual reports through the 17th International Congress of Immunology in 2019 here: The IG/TR/MH Nomenclature Sub-committee will practice in its governance and its partnerships:Ĭlick here to access the terms of reference for this Sub-committee This Sub-committee is also responsible for coordinating the biocuration of these genes in the appropriate germline gene database (e.g., IMGT). Marie-Paule Lefranc, the IG/TR/MH Nomenclature Sub-committee is responsible for validating, approving, and assigning names to newly discovered immunoglobulin (IG) and T-cell receptor (TR) germline genes and non-human MHC genes (MH), following the principles of the IMGT™ information system insofar as possible.
The following description of the Sub-committee’s goals, structure, and processes will be revised over the next several months as it responds to changes in the quantity and types of data available for understanding IG and TR germline gene polymorphisms, and as the Sub-committee strives to best serve the immunogenetics community. The IG/TR/MH Sub-committee adopted Terms of Reference in Spring 2022 outlining a democratic and transparent governance structure.
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